What is one of the main dangers associated with polysubstance use, particularly alcohol and marijuana?

One of the main dangers associated with polysubstance use, particularly when combining alcohol and marijuana, is the increased impairment and risk of accidents. Both substances individually affect the central nervous system, but when used together, their effects can be amplified. Alcohol impairs motor skills, reaction times, and judgment, while marijuana can affect coordination and cognitive function. This combination leads to a higher likelihood of accidents as individuals may overestimate their abilities and take risks they would normally avoid if sober. The synergistic effects can result in significant impairments that greatly increase the danger of driving or operating machinery, making this a critical point for understanding the risks associated with using multiple substances.